Cobra Queen is using her giant snakes to go on a crime spree, stealing jewelry and other apparel and accessories. She seems impossible to defeat, because she has ingeniously made her home in the sewer, which reeks of poo gas. The police are unwilling to follow, and Freakazoid is the city's only hope.
- Atomic Boy (mentioned; another of Cobra Queen's adversaries)
- Cobra Queen
- Sergeant Mike Cosgrove
- Officer Dan & Officer Mohammed-Abdul
- Giant Snakes
- Paul Harvey
- Woman making scary winds sounds (voiced by Tress MacNeille)
- Yakko & Wakko Warner (cameo on TV)
- This is the only Freakazoid! episode written by Kate Donahue. Donahue was in the Acme Comedy troupe with Paul Rugg and John P. McCann, and cowrote the Animaniacs short "Windsor Hassle" with Rugg and Lisa Malone, as well as cowriting the Pinky, Elmyra & the Brain episode "Cute Little Alienhead."